January 6th, 1984
Resident of Uppsala, Sweden
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Music, Painting, Science, Web design, Baking
E-mail: daniel.ocampo.daza /at/ gmail.com
Daniel Ocampo Daza
754 18 Uppsala
I received my M.Sc. in biology from Uppsala University in 2007 and subsequently pursued a doctorate under the supervision of prof. Dan Larhammar at the Department of Neuroscience, Uppsala University. I defended my thesis "Evolution of Vertebrate Endocrine and Neuronal Gene Families: Focus on Pituitary and Retina" on 1 March 2013, receiving a Ph.D. in medical science.
I have teaching qualifications and experience with lectures, small group seminars, practical tutoring, demonstrations and problem-based learning as well as course administration and curriculum building.
Download full CV here (PDF)
Evolution, Neuroscience, Endocrinology, Comparative endocrinology, Scientific writing, Molecular evolution, Sequence analysis, Phylogenetics, Genome Analysis, Gene prediction and annotation, Bioinformatics
Native/bilingual proficiency in Spanish and Swedish
Full professional proficiency in English
2013 — Ph.D. in Medical Science
Uppsala University, Department of Neuroscience
2007 — M.Sc. in Biology
Understanding our evolutionary past through the language of our genes
As vertebrates, we are united by a common ancestry spanning back some 500 million years to the Cambrian period. Since then we have evolved a great variety of different complex and specialized functions that have allowed us to occupy diverse ecological niches. Vertebrates live in almost every place on earth; from deep ocean trenches to arid deserts. The early evolution of vertebrates was a period of great innovation that set the foundation for this diversity. For instance, our mineralised bone structures and complex nervous systems go back to this period.
Genome: The total genetic content (DNA) in one set of chromosomes of an organism; including genes, regulatory sequences and non-functional DNA.
There is now convincing evidence that during a relatively short period of time our early ancestors got four times as much genetic material than before. This happened through two rounds of a process called whole-genome duplication. This must have had a great impact for our forbearers, because we can still find many of those duplicated genes in us today! A third whole-genome duplication happened early in the evolution of a group of fishes called teleosts
and this also had a great impact. The duplication of genes, segments of chromosomes, and especially entire genomes, is a force to be reckoned with in evolution because it creates new genetic material that mutation and selection can act on to generate new functions and evolutionary novelties.
: A scientific field and set of methods for the analysis of biological data using computers and statistical techniques.
In the previous decade we have seen an unprecedented advance in DNA sequencing technologies and bioinformatics tools. There is now openly available genome data from an ever growing number of organisms, including many vertebrates. This allows us to study the consequences of ancient whole-genome duplications and other evolutionary events with greater accuracy and resolution than ever. By our common ancestry, we can in practice study our common vertebrate past by comparing our DNA sequences with each other. Like archaeologists looking for clues to the past in the soil, or naturalists exploring new and unknown environments, we can wade through the vast stretches of DNA sequences in computers and explore the contents of different genomes; trying to identify genes and figuring out the puzzle of how they are related to each other and how they originated.
: A scientific field and set of methods to study how organisms or biological molecules are related through evolution. These evolutionary relationships are visualised through diagrams called phylogenetic trees.
This is the backdrop for my research, which addresses the evolution of endocrine and neurobiological gene families in vertebrates. That is, families of genes involved in the hormonal control of the body and in the nervous system. By combining genomic analyses with molecular phylogenetics it was possible to conclude that the ancient whole-genome duplications in vertebrates likely contributed greatly to the evolution of processes such as vision, neural communication, growth and osmoregulation (the control of water balance).
But it's not only an interesting evolutionary puzzle. Knowing more about our evolutionary past, where we come from and how we got here, and understanding it through the language of our genes, benefits all biological research. Functional studies can profit greatly from this genomic and evolutionary approach. Not least through the increased understanding of the important model organisms that are used in laboratories. Together with the fast development of DNA sequencing and the vast amounts of data that have been generated, this means that it has become essential for biologists of all fields to consult sequence databases and analyze genomic data. This is where my research is currently leading: To help bridge the gap between the fields of evolution, genomics and bioinformatics, and to facilitate their applications in functional research.
The identification and description of several new components of growth hormone and prolactin systems, oxytocin and vasopressin receptors as well as somatostatin receptors. Notably the discovery of prolactin 2
and several new subtypes of vasopressin type 2 receptors.
A better understanding of the history of whole genome duplications and chromosome rearrangements during vertebrate evolution.
A better understanding of the significant contribution of whole genome duplications and gene duplication to the evolution of vertebrates, and the diversification of functions such as vision, neural communication, growth and osmoregulation.
I have published eight articles that detail these findings, as well as been invited to present at several international conferences. The latest article was published in BMC Evolutionary Biology
this past November. I was also invited to co-author a review article in the Journal of Molecular Endocrinology
, which was published in April this year. Three more manuscripts are in preparation for submission later this year.
I aim to share all data files and supporting information underlying the scientific papers of which I am the principal author under Open Science principles. These principles include the freedom for anyone to use, reuse and redistribute the data and supporting information - subject only, at most, to the requirement to attribute and/or share-alike. To this effect, I share datasets openly using figshare
. These datasets are citable, using stable identifiers, and easily shared. Visit my figshare
Learn more about open science at the Open Knowledge Foundation
Lagman D†, Ocampo Daza D†, Widmark J, Abalo XM, Sundström G, Larhammar D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology, 13:238 - †Equal contributors
Open science | BioMed Central | PubMed | Altmetric | Impactstory | doi: 10.1186/1471-2148-13-238
Tostivint H, Ocampo Daza D, Bergqvist CA, Quan FB, Bougerol M, Lihrmann I, Larhammar D. (2014) Molecular evolution of GPCRs: Somatostatin/urotensin II receptors. Journal of Molecular Endocrinology, 52(3): T61-T86.
FREE | JME | PubMed | Altmetric | Impactstory | doi: 10.1530/JME-13-0274
Ocampo Daza D (2013) Evolution of Vertebrate Endocrine and Neuronal Gene Families: Focus on Pituitary and Retina. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206; 856
Free | DiVA | uri: urn:nbn:se:uu:diva-191829
These are simple illustrations of species whose genomes have been sequenced, as well as a few others. I created them for academic purposes such as lectures, presentations, posters et c. and thought I'd share them freely. You can see some examples of how they can be used here
. Preview all the illustrations by clicking on the link to the shared folder, or look at the sample image above.
I have licensed most of these illustrations under a Free Culture License by Creative Commons. This means that, with some exceptions*, you are free to use them for any purpose without asking for permission
as long as you attribute them to me, including a link to www.egosumdaniel.se. Click on the links provided in the license statement above to see more detailed information. Learn more about Creative Commons here
. I took precautions to use only non-copyrighted/non-restricted images as references for these illustrations. However, if you think a photo that you own the rights to or license exclusively has been used as a reference, please contact me at daniel.ocampo.daza /at/ gmail.com.
This license does not apply to any material posted from outside sources, or any other of my original material on Ego sum Daniel, which is licensed under a share-alike license
that prevents you from using my stuff in anything you or someone else will retain full copyright on.
Credits et License
— Daniel Ocampo Daza MMXIV —
All original content on Ego sum Daniel
by Daniel Ocampo Daza
is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License
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